Uninstall ThermoFlex™ API

How to completely remove the ThermoFlex™ Python API and its Python runtime.

We get it, sometimes you just need a clean slate. Whether you're troubleshooting an issue or preparing a fresh install for your next big demo, here’s how to completely remove the ThermoFlex™ Python API and its Python runtime.

This guide walks you through uninstalling:

• The thermoflex Python package

• Python itself

• Any residual environment variables or cached data

⚠️ Note: These steps are intended for Windows users. Please run all commands from PowerShell with administrator privileges.

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Step 1: Uninstall the ThermoFlex™ Python Package

If Python is still installed, open PowerShell and run:

pip uninstall thermoflex

If you’re running a specific Python version (e.g. 3.11), use:

py -3.11 -m pip uninstall thermoflex

Run it again until it confirms the package is no longer installed.

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Step 2: Uninstall Python

Option A: Uninstall via PowerShell

Get-WmiObject -Class Win32_Product | Where-Object { $_.Name -like "Python*" } | ForEach-Object {
    $_.Uninstall()
}

This will attempt to remove all Python distributions registered with Windows Installer.

Option B: Uninstall via Windows UI

If the PowerShell method doesn’t find anything, you can:

1. Press Win + R, type appwiz.cpl, and hit Enter

2. Scroll to any Python entries and click Uninstall

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Step 3: Clean Up Leftover Folders

Remove any leftover files, caches, or manually installed versions:

Remove-Item "$env:LocalAppData\Programs\Python" -Recurse -Force
Remove-Item "$env:AppData\Python" -Recurse -Force
Remove-Item "$env:LocalAppData\pip" -Recurse -Force

You can also check for:

Remove-Item "$env:ProgramFiles\Python*" -Recurse -Force -ErrorAction SilentlyContinue
Remove-Item "$env:ProgramFiles (x86)\Python*" -Recurse -Force -ErrorAction SilentlyContinue

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Step 4: Remove Environment Variables

Python sometimes leaves behind entries in your system PATH. To clean those:

$envVars = [System.Environment]::GetEnvironmentVariable("Path", "User") -split ";"
$filtered = $envVars | Where-Object { $_ -notmatch "Python" -and $_ -notmatch "pip" }
[System.Environment]::SetEnvironmentVariable("Path", ($filtered -join ";"), "User")

Then, clear any custom variables:

[System.Environment]::SetEnvironmentVariable("PYTHONPATH", $null, "User")
[System.Environment]::SetEnvironmentVariable("PYTHONHOME", $null, "User")

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Step 5: Confirm It’s Gone

Back in PowerShell, run:

where python

If it returns nothing, you’re fully clean.

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Next Steps

When you're ready, you can reinstall Python and follow our Getting Started Guide to set up your environment again, fresh and conflict-free.